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151. Occupational skin exposure to chemicals - CORE

The authors suggested that the probable determinants of sensitization are the N(CH 3) 2 or the N(C 2 H 5) 2 moieties in the para position of the benzene ring structure and that cross-reactivity is limited to substances with amino groups substituted with at least two alkyl groups (see Figure 1). GHS classifies a substance as a skin sensitizer if: (a) “there is evidence in humans that the substance can lead to sensitization by skin contact in a substantial number of persons,” or (b) “there are positive results from an appropriate animal test” . When considering the hierarchy of controls, this would mean either substituting for a non-sensitizing product or using technical controls to contain the product as much as possible. Nevertheless, there are several important points that should be considered: Remember to assess all potential routes of exposure. ‘substance’ means a chemical element and its compounds in the natural state or obtained by any manufacturing process, including any additive necessary to preserve its stability and any impurity deriving from the process used, but excluding any solvent which may be separated without affecting the stability of the substance or changing its composition; Respiratory sensitizer means a chemical that will lead to hypersensitivity of the airways following inhalation of the chemical (See Appendix A to 29 CFR 1910.1200, section A.4.). In contrast to respiratory irritation, respiratory sensitization is an immunological response to previous exposure to a chemical. Assess substances used at work including any new substances introduced.

Sensitiser mean on the packaging of a substance

sensitiser - Dictionary definition and meaning for word sensitiser Definition (noun) (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction 1. A respiratory sensitiser is a substance that will induce hypersensitivity of the airways following inhalation of the substance. 2. A contact sensitiser is a substance that will induce an allergic response following skin contact. CONSIDERATIONS 3.

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The percentage of the sensitiser is below the generic concentration limit (of ≥1.0%) in Table 3.4.5 of Annex I of the EC Regulation 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP) that would trigger the classification of the mixture as a respiratory sensitiser, but above the concentration … Princeton's WordNet (3.00 / 1 vote) Rate this definition: sensitizer, sensitiser (noun) (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction. sensitiser - Dictionary definition and meaning for word sensitiser Definition (noun) (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction 2016-01-13 The packaging of products containing 0.1% of a sensitizer must bear the inscription “Contains ‘name of sensitizer’. May produce an allergic reaction.” The aim is to protect individuals already sensitized by providing information which enables them to avoid products containing ingredients which may … 2018-09-02 Substances can be classified as skin sensitisers if there is evidence from experimental tests or in humans that the substance can lead to sensitisation by skin contact. From information in the Classification and Labelling Inventory, there are over 14 000 substances on the EU market with some indication of a skin sensitising concern.

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Sensitiser mean on the packaging of a substance

(See Appendix A to 29 CFR 1910.1200, section A.4.) In contrast to skin irritation, skin sensitization is an immunological response to previous exposure to a substance which results in … Sensitizer or sensitiser may refer to: . Chemical sensitizer, a chemical that causes allergic reaction in normal tissue after exposure; Explosive sensitizer, a chemical that promotes the rate of propagation of an explosive; see Chemical explosive#Sensitizer; Photosensitizer, a chemical that is involved in photoelectrochemical processes 2019-03-27 2021-01-06 The European Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures – the CLP Regulation – came into force in all EU member states, including the UK, on 20 January 2010. The CLP Regulation: adopts in the EU the Globally Harmonised System (GHS) on the classification and labelling of chemicals; The first step in regulatory evaluation of substances involves the identification of their intrinsic hazards, including the potential for skin sensitization. This is, quite properly, entirely different from assessment of the risks to human health, which might arise from incorporation of substances i … GHS classifies a substance as a skin sensitizer if: (a) “there is evidence in humans that the substance can lead to sensitization by skin contact in a substantial number of persons,” or (b) “there are positive results from an appropriate animal test” . History. Eric Kandel was one of the first to study the neural basis of sensitization, conducting experiments in the 1960s and 1970s on the gill withdrawal reflex of the seaslug Aplysia.Kandel and his colleagues first habituated the reflex, weakening the response by repeatedly touching the animal's siphon.

A contact sensitiser is a substance that will induce an allergic response following skin contact. CONSIDERATIONS 3. The purpose of the harmonised criteria for classification of respiratory and skin sensitisers is GHS Classification Criteria for Skin Sensitization. Little Pro on 2017-11-08 Views: . A chemical substance will be classified as a skin sensitizer if there is reliable human evidence or positive results from an appropriate animal test. A respiratory sensitiser is a substance which, when it is breathed in, can lead to occupational asthma, which is an allergic reaction in the lungs.
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Skin. Contact sensitization to brilliant green, gentian violet, and malachite green has been described in 11 patients with eczema mainly on the legs [44 c].There was sensitization to brilliant green in all 11, with simultaneous sensitivity to gentian violet in eight and to malachite green in six; triphenylmethane and para-rosaniline produced Links to industry guidance, forms and inventories for food packaging and food contact substances. The process by which your body becomes sensitive to—and allergic to—a particular substance is called sensitization. When your immune system becomes sensitized to an allergen (an otherwise harmless substance), you will likely develop symptoms of an allergy each time you are … – UN Globally Harmonised System for Classification, labelling and packaging (GHS/CLP) – REACH – Cosmetics Directive Info traditionally obtained with animal tests – Guinea pig tests, Local Lymph Node Assay (LLNA) Information on potency if a substance is a skin sensitiser often required – Intrinsic strenght to induce sensitisation toxicity) to the aquatic environment; and a new hazard class for substances and mixtures hazardous to the ozone layer. 9. At its fifth session (10 December 2010) the Committee of Experts adopted a set of amendments to the third revised edition of the GHS which were consolidated in document ST/SG/AC.10/38/Add.3.

WHERE SENSITIZERS ARE FOUND The OSHA Hazard Communication Standard, or HCS, defines a sensitizer as “a chemical that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the chemical” (emphasis added). Sensitizers are present environmentally and occupationally in many different industries including Greet Teuns, in Nonclinical Assessment of Abuse Potential for New Pharmaceuticals, 2015. 2.3 Sensitization. Sensitization (the opposite of tolerance) to active substances is defined as an increased effect of the substance following repeated doses. In particular, behavioral sensitization or psychomotor sensitization can be observed in animals treated with stimulants, as evidenced by enhanced ‘substance’ means a chemical element and its compounds in the natural state or obtained by any manufacturing process, including any additive necessary to preserve its stability and any impurity deriving from the process used, but excluding any solvent which may be separated without affecting the stability of the substance or changing its composition; Respiratory sensitizer means a chemical that will lead to hypersensitivity of the airways following inhalation of the chemical (See Appendix A to 29 CFR 1910.1200, section A.4.). In contrast to respiratory irritation, respiratory sensitization is an immunological response to previous exposure to a chemical.
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1. A respiratory sensitiser is a substance that will induce hypersensitivity of the airways following inhalation of the substance. 2. A contact sensitiser is a substance that will induce an allergic response following skin contact.

A respiratory sensitiser is a substance which, when it is breathed in, can lead to occupational asthma, which is an allergic reaction in the lungs. Once a person has developed asthma (or has been 'sensitised'), any further exposure to the substance can produce the same reaction. You may not develop asthma immediately after working with a substance. sensitiser.
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Links to industry guidance, forms and inventories for food packaging and food contact substances. 2013-01-10 · 1. Introduction. Identification or categorization of sensitizing chemicals to skin is an important process in chemical risk assessment. Current classifications of skin sensitizers have mostly been achieved using the mouse local lymph node assay (LLNA) and guinea pig tests, including the Buehler test or guinea pig maximization test (GPMT) (Kimber et al., 1995, Kimber and Weisenberger, 1989 What does PTNSR mean? PTNSR as abbreviation means "Packaging and Transport of Nuclear Substances Regulations".